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There is growing awareness that the profound changes in the environment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry ≈10000 y ago occurred too recently on an evolutionary time scale for the human genome to adjust.

In conjunction with this discordance between our ancient, genetically determined biology and the nutritional, cultural, and activity patterns of contemporary Western populations, many of the so-called diseases of civilization have emerged.

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When the environment remains relatively constant, stabilizing selection tends to maintain genetic traits that represent the optimal average for a population (2).

When environmental conditions permanently change, evolutionary discordance arises between a species’ genome and its environment, and stabilizing selection is replaced by directional selection, moving the average population genome to a new set point (1, 2).

Initially, when permanent environmental changes occur in a population, individuals bearing the previous average status quo genome experience evolutionary discordance (2, 3).

In the affected genotype, this evolutionary discordance manifests itself phenotypically as disease, increased morbidity and mortality, and reduced reproductive success (1-3).




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